Mishra L, Banker T, Murray J, Byers S, Thenappan A, He AR, Shetty K, Johnson L, Reddy EP. Liver stem cells and hepatocellular carcinoma. Hepatology. 2009 Jan;49(1):318-29. (abstract)
Baek HJ, Lim SC, Kitisin K, Jogunoori W, Tang Y, Marshall MB, Mishra B, Kim TH, Cho KH, Kim SS, Mishra L. Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology. 2008 Oct;48(4):1128-37. (abstract)
Amin R, Mishra L. Liver stem cells and TGF-ß in hepatic carcinogenesis. Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S27-30. (pdf article | abstract)
Glasgow E, Mishra L. Transforming growth factor-beta signaling and ubiquitinators in cancer. Endocrine-Related Cancer. 2008 Mar;15(1):59-72. (pdf article | abstract)
Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, Ressom HW, Rashid A, He AR, Mendelson JS, Jessup JM, Shetty K, Zasloff M, Mishra B, Reddy EP, Johnson L, Mishra L. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-ß and IL-6 signaling. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2445-50. (pdf article | abstract)
Laguinge LM, Samara RN, Wang W, El-Deiry WS, Corner G, Augenlicht L, Mishra L, Jessup JM. DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. Cancer Res. 2008 Feb 1;68(3):909-17. (pdf article | abstract)
Yun C, Mendelson J, Blake T, Mishra L, Mishra B. TGF-ß signaling in neuronal stem cells. Dis Markers 2008;24(4-5):251-5. (abstract)
He AR, Mendelson J, Blake T, Mishra L, Marshall JL. Stem cells in gastrointestinal cancers. Dis Markers. 2008;24(4-5):217-22. (pdf article)
Kitisin K, Pishvaian MJ, Johnson LB, Mishra L., Marshall, B. Liver stem cells and molecular signaling pathways in hepatocellular carcinoma. Gastrointest Cancer Res 2007 Jul;1(4 Suppl 2):S13-21. (pdf article | abstract)
Kitisin K, Saha T, Blake T, Kim C, Deng M, Mishra B, Mishra L. TGF-ß Signaling in Development. Science STKE (Connections Map, http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18196, peer review). (Description)
Blake T, Ganesan N, Shetty K, Mishra L. TGF-ß Signaling in Gastrointestinal Stem Cells. Science STKE (Connections Map, http://stke.sciencemag.org/cgi/cm/stkecm;CMP_17699, peer review).
(Description)
Baek, H.J., Kim S.S., Da Silva FM. Volpe EA, Evans S, Mishra B, Mishra L., Marshall, B. Inactivation of TGF-ß signaling in lung cancer results in increased CDK4 activity that can be rescued by ELF. Biochemical and Biophysical Research Communications 11; 346(4):1150-7. (pdf article | abstract)
Golestaneh, N., Tang, Y., Katuri, V., Mishra, L., Mishra, B.2006 Cell Cycle deregulation and loss of stem cell phenotype in the Subventricular Zone of TGF-ß adaptor elf-/- mouse brain. Brain Research 1108: 45-53. (abstract | pdf article)
Faler BJ, Macsata RA, Plummer D, Mishra L, Sidawy AN. 2006. Transforming growth factor-beta and wound healing. Perspect Vasc Surg Endovasc Ther. 18(1):55-62. (abstract)
Kim, S.S., Shetty, K., Katuri, V., Kitisin, K., Baek, H.J., Tang, Y., Marshall, B., Johnson, L.B., Mishra, B., Mishra, L. 2006. TGF-ß Signaling Pathway Inactivation and Cell Cycle Deregulation in the Development of Gastric Cancer: Role of the ß-Spectrin, ELF. Biochemical and Biophysical Research Communications 16;344 (4):1216-23. (abstract | pdf article)
Katuri V, Tang Y, Li C, Jogunoori W, Deng C, Rashid A, Sidawy A, S Evans, Mishra B, Mishra L. 2006. Critical interactions between TGF-ß Signaling/ELF and E-Cadherin/ß-Catenin Mediated Tumor Suppression. Oncogene 25(13):1871-86. (abstract | pdf article)
Saha T, Yerraguntla D, Tang Y, Katuri V, Jogunoori W, Volpe EA, Haines D, Sidawy A, Zhou X, Gallicano I, Schlegel R, Mishra B, Mishra L. 2006. RING Finger-Dependent Ubiquitination by PRAJA is Dependent on TGF-ß and Potentially defines the Functional Status of the Tumor Suppressor ELF. Oncogene 25(5):693-705. (abstract | pdf article)
Wang R, Li C, Xu X, Zheng Y, Xiao C, LeRoith D, Zerfa P, Eckhaus M, Mishra L., Deng, C. 2005. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metabolism 2:399-409. (abstract | pdf article)
Katuri V, Tang Y, Marshall B, Rashid A, Jogunoori W, Volpe EA, Sidawy AN, Evans S, Blay J, Gallicano GI, Premkumar Reddy E, Mishra L, Mishra B. 2005. Inactivation of ELF/TGF-ß signaling in Human Gastrointestinal Cancer. Oncogene 24: 8012-8024. (abstract | pdf article)
Mishra L, Derynck R, and Mishra B. 2005. Transforming Growth Factor-ß Signaling in Stem Cells and Cancer. Science 310 (5745): 68-71. (abstract | pdf article)
Golestaneh N, Mishra B. TGF-beta, neuronal stem cells and glioblastoma. Oncogene. 2005 Aug 29;24(37):5722-30. (abstract | pdf article)
Mishra, L. Katuri, V. Evans, S. 2005. The Role of PRAJA and ELF in TGF-ß Signaling and Gastric Cancer. Cancer Biology & Therapy 4(7): 694-699. (abstract | pdf article)
Tang Yi, Katuri V, Srinivasan R, Fogt F, Redman R, Anand G, Said A, Fishbein T, Zasloff M, Reddy P, Mishra B, Mishra L. 2005. Transforming growth factor-ß Suppresses Nonmetastatic Colon Cancer through Smad4 and Adaptor Protein ELF at an Early Stage of Tumorigenesis. Cancer Research. 65: 4228-4237. (abstract | pdf article)
Redman S, Katuri V, Tang Yi, Dillner A, Mishra B, Mishra L. 2005. Orofacial and gastrointestinal hyperplasia and neoplasia in Smad4+/- and elf+/-/Smad4+/- mutant mice. J Oral Pathol Med. 3:23-9. (abstract)
Mishra B, Tang Y, Katuri V, Fleury T, Said AH, Rashid A, Jogunoori W and Mishra L (2004) Loss of Cooperative Function of TGF-ß Signaling Proteins, Smad3 with ELF, a ß-Spectrin, in Primary Biliary Cirrhosis. Liver Int 24:637-45. (abstract | pdf article)
Tang Y, Katuri V, Dillner A, Mishra B, Deng CX, Mishra L. 2003. Disruption of TGF-ß signaling in ELF ß-spectrin deficient mice. Science, 299: 574-577. (abstract | pdf article)
Tang Y, Katuri V, Iqbal S. Narayan T, Wang X, Lu RS, Mishra L, Mishra B. 2002. ELF, a ß-Spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene. Oncogene, 21(34): 5255-5267. (abstract | pdf article)
Harbord M, Dawes RF, Barr H, Giovannini M, Viens P, Eysselein V, Mishra L, Orenberg EK, Bown SG. 2002. Palliation of patients with dysphagia due to advanced esophageal cancer by endoscopic injection of cisplatin/epinephrine injectable gel. Gastrointest Endosc. 56(5): 644-51.
(abstract)
Bhanumathy CD, Tang Y, Monga SP, Katuri V, Cox JA, Mishra B, Mishra L. 2002. ITIH-4, A serine protease inhibitor regulated in Inter Leukin-6 dependent liver formation: role in liver development and regeneration. Developmental Dynamics 223:59-69. (abstract | pdf article)
Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Yi, Li C, Mishra L, Deng CX. 2001. Smad proteins and Hepatocyte growth factor control parallel regulatory pathways that converge on ß1- integrin to promote normal liver development. Mol Cell Biol 21(15): 5122-5131. (abstract | pdf article)
Monga SP, Tang Y, Candotti F, Rashid A, Wildner O, Mishra B, Iqbal S, Mishra L. 2001. Expansion, of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants. Cell Transplantation 10: 81-89. (abstract)
Monga SP, Wadleigh R, Sharma A, Adib H, Strader D, Singh G, Harmon JW, Berlin M, Monga DK, Mishra L. 2000. Intratumoral therapy of cisplatin/epinephrine injectable gel for palliation in patients with obstructive esophageal cancer. Amer. J Cl. Oncology 23(4): 386-392.
Mishra L, Cai T, Yu P, Monga SP, Mishra B. 1999. ELF3 encodes a novel 200 KD ß-spectrin: role in liver development. Oncogene 18:353-364.
(abstract | pdf article)
Mishra L, Yu P, Cai T, Monga SP, Mishra B.1999. Genomic structure, chromosomal mapping, and muscle-specific expression of a PH domain-associated intronless gene, cded/lior. Mamm Genome 10:62-7. (abstract)
Cai T, Yu P, Monga SP, Mishra B, Mishra L. 1998. Identification of mouse itih4 encoding a glycoprotein with two EF-hand motifs from early embryonic liver. Biochim Biophys Acta 1398:32-37.
(abstract | pdf article)
Mishra L, Bass B, Ooi BS, Sidawy A, Korman L. 1998. Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers. Growth Horm IGF Res. 8(6):473-9. (abstract)
Monga SP, Wadleigh R, Adib H, Harmon JW, Berlin M, Mishra, L. 1998. Endoscopic treatment of gastric cancer with intratumoral cisplatin/epinephrine injectable gel: a case report. Gastrointes. Endoscopy 48:415-417.
Mishra L, Cai T, Levine A, Weng D, Mezey E, Mishra B, Gearhart J. 1998. Identification of elf1, a ß-spectrin, in early mouse liver development. Int J of Dev. Biol 42: 221-4.
(abstract | pdf article)
Mishra L., Voyles N, Bass B, Korman L. 1997. Role of IGF-1, IGF-IR and IGFBP-2 in the regulation of human colon cancer. Growth Reg. 7.1.1-10.
Burris HA 3rd, Vogel CL, Castro D, Mishra L, Schwarz M, Spencer S, Oakes DD, Korey A, Orenberg EK 1998. Intratumoral Cisplatin/Epinephrine Injectable Gel as a Palliative Treatment for Accessible Solid Tumors: A Multicenter Pilot Study. Otolaryngol Head and Neck Surg 118:496-503. (abstract)
Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan WJ, Mishra B. 1997. Praja 1, a novel gene encoding a RING-H2 motif in mouse development . Oncogene.15, 2361-2368.
(abstract | pdf article)
Wu T, Rezai B, Rashid A, Luce MC, Cayouette MC, Kim C, Sani N, Mishra L, Moshaluk CA, Yardley JH, Hamilton SR. 1997. Genetic alterations and epithelial dysplasia in juvenile polyposis syndrome and sporadic juvenile polyps. AM. J Path . 150(3): 939-947. (abstract)
Mishra L, Mishra BB, Harris M, Bayless TM, Muchmore AV.1993. In vitro cell aggregation and cell adhesion molecules in Crohn's disease. Gastroenterology. 104(3):772-9. (abstract)
Mishra L, Ooi BS. 1993. Biosynthesis of colony stimulating factor I (CSF-1) by mesangial cells of autoimmune mice. Immunol Invest 22(3), 249-255. (abstract)
Benya R, Duncan M, Mishra L, Bass B, Voyles N, Korman L. 1993. Extracellular matrix composition influences Insulinlike growth factor I receptor expression in rat fetal small intestinal cell line (IEC - 18). Gastroenterology 104:1705-1711. (abstract)
Mishra L, Seeff LB. 1992 Viral hepatitis, A though E, complicating pregnancy. Gastroenterol Clin North Am. 21(4):873-87. (abstract)
Mishra L, Le NA, Brown WV, Mezey E. 1991. Effect of acute intravenous alcohol on plasma lipoproteins in man. Metabolism 40: 1128-1130. (abstract)
Mishra L, Rose JA. 1990. Adeno-associated virus DNA replication is induced by genes that are essential for HSV-1 DNA synthesis. Virology. 179(2):632-9.
Mezey E, Potter JJ, Mishra L, Sharma S and Janicot M. 1990. Effect of insulin-like growth factor I on rat alcohol dehydrogenase in primary hepatocyte culture. Arch Biochem Biophys 280:390-396. (abstract)
Mishra L, Sharma S, Potter JJ, Mezey E. 1989. More rapid elimination of alcohol in women as compared to their male siblings. Alcohol Clin Exp Res 13:752-754. (abstract)
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Reviews
Kitisin, K., Mishra, L. Molecular biology of colorectal cancer: New Targets. Semin Oncol. 2006 Dec;33 Suppl 11:14-23.
Mishra, L, Marshall, B. 2006 Adaptor Proteins and Ubiquinators in TGF-ß Signaling. Cytokine and Growth factor Reviews 17(1-2):75-87. (abstract | pdf article)
Mishra, L. and Roberts, A. 2005. Role of TGF-ß in Stem Cells and Cancer. Oncogene Reviews, 24: 5667. (Editors: L. Mishra, A. Roberts). (pdf article)
Mishra, L., Shetty, K., Tang, Y., Stuart, A., Byers, S. 2005. The Role of TGF-ß and Wnt Signaling in Gastrointestinal Stem Cells and Cancer. Oncogene Reviews, 24, 5775-5789. (Editors: L. Mishra, A. Roberts). (abstract | pdf article)
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Books
Kim S Shuman, Mishra L. Interaction of Smad4 and Embryonic Liver Fodrin (ELF)-ß-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression. 2005 (Transforming Growth Factor-beta in Cancer Therapy) Humana press, Inc.
Mishra L. Mouse Knockout Models of Biliary Epithelial Cell Formation and Disease. 2004 (The Pathophysiology of biliary epithelial. Eds Alpini, Alvaro,, Marzioni, LeSage, LaRusso) Landes biosciences, Texas.
Mishra L, Voyles N, Shafer L, Mishra B, Mezey E,Gearhart J.Characterization of Sc32, a novel marker identifying early liver development. Molecular Genetics of development, Airlie, Virginia, 1994
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Abstracts
Mishra L, Mishra BB, Muchmore AV, Bayless TM.1988.In vitro intercellular adhesion and granuloma formation in Crohn's disease. Gastroenterology 94/5:A305
Mishra L, Sharma S, Potter JJ and Mezey E.1989 More Rapid elimination of alcohol in women as compared to their male siblings. Gastroenterology 96:A631
Mishra L, Mishra BB, Bayless TM, Muchmore AV. Mac-1 mediated cell adhesion in granuloma formation seen in Crohn's disease. International Congress of Immunology, Berlin, 1989.
Hakim F, Voyles NR, Bass B, Mishra L, Korman LY. “Insulin-like growth factor-I binding to human colon cancer: inhibition by an hIGF-I structural analogue,” Gastroenterology, 102, 4, A736, 1992.
Mishra L, Bankert L, Voyles N, Gearhart J, Mishra B, Korman L, Mezey E. “Characterization of differentially expressed mRNAs in mouse embryonic liver,” Hepatology, 16, 4, 186A, 1992.
Mishra L, Voyles N, Shetty S, Hakim F, Bass B, Korman LY. “Insulin like growth factor binding protein-2 gene expression is upregulated in human colorectal cancer,” Gastroenterology, 104, 4, A840, 1993.
Mishra L, Bankert N, Voyles B, Mishra B, Gearhart J, Mezey E. “Characterization of a novel stage-specific gene (SC 32) isolated from developing liver,” Gastroenterology, 104, 4, A956, 1993.
Mishra L, Mishra BB, Phillips SM, Muchmore AV, Bayless TM. 1993. Influence of cell adhesion molecules in granuloma formation by mononuclear cells in Crohn's disease. Gastroenterology.104: 772-779.
Mishra L, Voyles N, Bass B, Korman L.Potential role of IGF-1, IGF-IR and IGFBP-2 in the regulation of human colon cancer.Gastroenterology (1994), 96, A631.
Mishra L, Reilly J, Rofail M, Peters B, Kozam M L, Wadleigh R.Successful treatment of esophageal cancer with endoscopic injection of methotrexate and cisplatin therapeutic injectable gels.(1995) Gastroenterology, 108,4, A168.
Forsyth E, Voyles N, Shafer, L, Mishra B, Sidawy A, Korman L, Mishra L. Growth inhibition of a human colon cancer cell line by antisense oligonucleotides to IGFBP-2.1995) Gastroenterology, 108,4, A726.
Mishra L, Tully R, Cai T. ELF and ELP, characterized by pleckstrin homology domains, define meso-endodermal interactions in early liver deveopment. Keystone Symposium on Inductive Interactions during Vertebrate Embryogenesis. Feb 1996.
Monga SPS, Tully RE, Cai T, Kos L, Mishra B, Pavan W, Mishra L. “LIV 88, a novel goliath-related gene encoding a RING-H2 motif in hepatocyte growth and differentiation,” Gastroenterology, 112, 4, A1336, 1997.
Monga DK, Berlin MJ, Harmon J, Adib H, Wadleigh R, Mishra L. “Endoscopic administration of intratumoral cisplatin/epinephrine injectable gel for treatment of gastric cancer,” Gastroenterology, 112, 4, A617, 1997.
Yu P, Cai T, Monga SPS, Mishra B, Mishra L. “Structural and expression of Cded, a novel gene encoding a PH domain, maps to the digital portion of mouse chromosome 2,” Gastroenterology, 114, 4, A-1370,1998.
Cai T, Yu P, Monga SPS, Mishra B, Mishra L. “Molecular cloning and expression of mouse ITIH-4: encodes a scaffolding protein in liver formation,” Gastroenterology, 114, 4, A1218, 1998.
Monga SPS, Wadleigh R, Adib H, Mishra L. “Endoscopic intratumoral injection of cisplatin/epinephrine as palliation for advanced esophageal and gastric cancer: long term outcome,” Gastroenterology, 114, 4, A645, 1998.
Cai T, Yu P, Monga SPS, Mishra B, Mishra L. “elf3, a novel ß-spectrin gene in liver and bile duct development,” Gastroenterology, 114, 4, A516, 1998.
Monga SPS, Rahman A, Subramanian A, Mishra L. “Early liver development is heralded by scaffolding, anchoring and trafficking proteins important in the generation of structural and functional polarity,” Hepatology, 28, 4, 31A, 1998.
Cox J, Monga SPS, Mishra B, Mishra L. “Functional characterization of ITIH-4, a scaffolding protein isolated from developing liver,” Hepatology, 28, 4, 32A, 1998.
Monga SPS, Lee J, Lin HZ, Diehl AM, Rashid A, Mishra L. PRAJA-1 and ELF cell polarity proteins from developing liver expressed at different and distinct time points during liver regeneration,” Hepatology, 28, 4, 33A, 1998.
Monga SPS, Kruse D, Redman R, Mishra B, Mishra L. “A novel RING finger protein PRAJA1 is required for maintenance of developing liver architecture,” Hepatology, 28, 4, 390A, 1998.
Subramanian A, Mishra L. “Cloning of a novel gene, AVP36, from embryonic liver and necessary for protein trafficking and sorting,” Hepatology, 28, 4, 593A, 1998.
Monga SPS, Rashid A, Wildner O, Condotti F, Mishra L. “Ex vivo embryonic liver explant cultures: a model for studying liver development,” Hepatology, 28, 4, 603A, 1998.
Rahman A, Mishra L. “Characterization of LCA: a novel gene encoding a short chain collagen polypeptide expressed in multiple endodermal and mesodermal cells,” Hepatology, 28, 4, 640A, 1998.
Monga S.P.S., Kennedy J., Mishra B., Dhanasekaran D. and Mishra L. “Praja-1, a Novel Ring Finger Protein Involved in Hepatocyte Apoptosis is Selectively Expressed in Hepatocyte Stem Cells,” Gastroenterology, 116, 4, A465, 1999.
Weinstein M., Monga S.P.S., Rashid A., Deng C-X, Mishra L. “SMAD 2/3 Deficiency Defines an Essential Developmental Checkpoint in Liver Formation,” Gastroenterology, 116, 4, A566, 1999.
Monga S.P.S., Rashid A., Wildner O., Condotti F., Mishra B. and Mishra L. “Growth and Culture of Hepatic Stem Cells Utilizing Liver Explant Cultures,” Gastroenterology, 116, 4, A1247, 1999.
Monga S.P.S., Tang Y., Rashid A., Mishra B. and Mishra L. “Ontogeny, Function and Role in Liver Regeneration of ITIH-4, a Liver Specific Serine Protease Inhibitor,” Gastroenterology, 116, 4, A1247, 1999.
Mishra L., Monga S.P.S., Weinstein M., Rashid A., Laxman R. and Deng C-X. “Effects of Ethanol and Lipopolysaccharine on Livers of FGFR4 and FGFR3/4 Knockout Mice,” Gastroenterology, 116, 4, A1247, 1999.
Monga S.P.S., Danovitch S., Rashid A., Mishra B., Fleury T. and Mishra L. “Correlation of Inhibition Studies of ELF-3 a ß-Spectrin with Primary Biliary Cirrhosis,” Gastroenterology, 116, 4, A1248, 1999.
Mishra L, Tang Y, Monga SPS, Weinstein M, Yang X, Rashid A, Diehl AM, Deng C. "Ontogeny and role in liver regeneration of smad2 and smad3; essential components in liver formation," Gastroenterology, 116, 4, A1248, 1999.
Monga SPS, Weinstein M, Rashid A, Tang Y, Iqbal S, Deng C, Mishra L. “3147 essential cooperative function of the TGF-Beta signaling molecules SMAD2/3 for liver formation can be rescued by HGF,” Hepatology, 30, 4, 318A, 1999.
Mishra L, Monga SPS, Rashid A, Danovitch S, Fleury T, Iqbal SA, Tang Y, Deng C, Mishra B. “3147 disruption of TGF Beta signaling by smad2, smad3, and ELF spectrins in primary biliary cirrhosis,” Hepatology, 30, 4, 401A, 1999.
Mishra L, Tran PT, Bhanumathy CD, Tang Y, Rashid A, Danovitch S, Fleury T, Mishra B, Deng C. “TGF Beta signaling by SMAD2/3 and ELF spectrins results in bile duct formation and is disrupted in primary biliary cirrhosis,” Gastroenterology, 118, 4, A2, 2000.
Tang Y, Candotti F, Mishra B, Iqbal S, Mishra L. “Retroviral-mediated expression of the green fluorescent protein and expansion of embryonic gut, hepatic, and hematopoietic stem cells,” Gastroenterology, 118, 4, A295, 2000.
Deng C, Mishra L. “TGF-Beta signaling by SMADS in gastrointestinal development and cancer,”Gastroenterology, 118, 4, A187, 2000.
Banumathy C, Tang Y, Mishra B, Mishra L. “ Itih-4, a serine protease inhibitor plays a prominent functional role in IL-6 induced hepatocyte formation,” Gastroenterology, 120, 5, A-27, 2001.
Tang Y, Danovitch S, Fleury T, Mishra B, Deng C, Mishra L. “Defects in TGF Beta signaling by smad4 and ELF spectrins are associated with gastric carcinogenesis,” Gastroenterology, 120, 5, A-495, 2001.
Tang Y, Subramanian A, Fox C, Banumathy C, Radhakrishnan S, Mishra B, Mishra L. “Novel ring finger proteins PRAJA-1 and AVP-36 play distinct roles in ubiquitination and protein trafficking in epithelial cell formation,” Gastroenterology, 120, 5, A-302, 2001.
Katuri V, Tang Y, Fox C, Dillner A, Agarwal P, Danovitch S, Fleury T, Mishra B, Deng C, Sidawy A, Mishra L. “Defects in TGF-ß singaling by SMAD4 and ELF-ß spectrins are associated with gastric carcinogenesis,” Gastroenterology, 122, 4, A-114, 2002.
Tang Y, Katuri V, Dillner A, Mishra B, Deng C, Mishra L. “Genetic evidence for the essential role of a novel ß-spectrin ELF in the TGF-ß-signaling transduction pathway and gut epithelial cell polarity,” Gastroenterology, 122, 4, A-95, 2002.
Katuri V, Tang Y, Dillner A, Mishra B, Mishra L. Gastrointestinal Tumorigenesis in Elf And Smad4 Mutant Mice. Gastroenterology, 124, 4, A-605, S1, 2003.
Tang Y, Katuri V, Dillner A, Mishra B, Mishra L. Adaptor Proteins ELF, SARA, Filamin and Microtubule Modulation of TGF- ß Signaling in ELF Deficient Mice. Gastroenterology, 124, 4, A-66, S1, 2003.
Katuri V, Tang Y, Dillner A, Fleury T, Danovitch S, Mishra B, Deng CX, Mishra L, Genetic Support for a Critical Role for TGF-ß Signaling in Gastric Cancer in ELF Deficient Mice. Gastroenterology, 124, No.4, A-20, S1, 2003.
Katuri V, Tang Y, Allan Dillner, Mishra B, Mishra L, Aberrant Gut Epithelial Cell Polarity in Elf Deficient Mice with Disruption of TGF- ß Signaling. Gastroenterology, 124, No.4, A-279, S1, 2003.
Tang Y, Katuri V, Allan Dillner, Danovitch S, Mishra B, Mishra L, ELF is a Key Adaptor for TGF- ß Signaling, Liver Development and Hepatocellular Cancer. Gastroenterology, 124, No.4, A-34, S1, 2003.
Vardhini D, Tang Y, Katuri V, Jogunoori W, Said AH, Haines D, Mishra L, Mishra B. Ring Finger-Dependent Ubiquitination by PRAJA Potentially Defines the Functional Status of the Tumor Suppressor SMAD4. Hepatology, 40, 4, 605a, S1, 2004.
Katuri V, Tang Y, Cui C, Jogunoori W, Deng CX, Sidawy AN, Mishra B, Reddy EP, Mishra L. Critical Role of ELF/TGF-? Signaling in Hepatocellular Cancer Suppression. Hepatology, 40,4, 187A, S1, 2004.
Jogunoori W, Katuri V, Tang Y, Mishra B, Mishra L. Growth regulation by TGF-ß is abrogated by Multiple Mechanisms in Gastrointestinal Tumors in elf/Smad4 Mutant Mice. Gastroenterology, 126, No.4, A-137, S964, S2, 2004.
Tang Y, Vardhini D, Katuri V, Mishra B, Mishra L. TGF-ß Suppresses Nonmetastatic Colon Cancer Through Smad4 and Adaptor Protein ELF at an Early Stage of Tumorigenesis. Gastroenterology, 126, No.4, A-79, 626, S2, 2004.
Katuri V, Tang Y, Mishra B, Mishra L. Role of ELF- a ß-Spectrin and Smad4 in TGF-ß Signaling and Digestive Tract Tumors. Gastroenterology, 126, No.4, A-269, M962, S2, 2004.
Katuri V, Tang Y, Jogunoori W, Sidawy AN, Mishra B, Reddy EP, Mishra L. Inactivation of TGF-ß Signaling Through ELF Disrupts E-cadherin/ ß-Catenin Dependent Epithelial Cell-Cell Adhesion and Leads to widespread Development of Digestive Tract Tumors. Gastroenterology, 126, No.4, A-38, 334, S2, 2004.
Fishbein T, Said AH, Zasloff MA, Katuri V, Tang Y, Mayor L, Mishra B, Mishra L. Disruption of TGF¬-ß Signaling: Aberrant SI Phenotype in ELF Deficient Mice and Human Intestinal Transplant (ITX) Rejection. Gastroenterology, 126, No.4, A-300, M1122, S2, 2004.
Vardhini D, Tang Y, Anan H Said, Varalakshmi Katuri, Bibhuti Mishra, Lopa Mishra. RING Finger-Dependent Ubiquitination by PRAJA Potentially defines the Functional Status of the Tumor Suppressor Smad4. Gastroenterology, 126, No.4, A-80, 630, S2, 2004.
Katuri V., Baker S., Tang Y., Reddy E.P., Mishra B., and Mishra L. Cross-talk between TGF-?-Myb is important for gastro-intestinal epithelial cell differentiation. Gastroenterology 128, No 4, A-492, T1501, S2, 2005.
Jogunoori W., Johnson L., Tang Y., Katuri V., Shetty K., Mishra B., Mishra L.TGF-ß-signaling is required for ductal progenitor cell survival and epithelial cell differentiation in normal liver. Gastroenterology 128, No 4 A-353, M1498, S2, 2005.
Shetty K., Johnson L., Volpe E., Evans S., Fishbein, Tang Y., Katuri V., Mishra L. TGF-ß-signaling pathway inactivation and cell cycle deregulation in human Gastric, Cell Lines and elf+/-/Smad4+/- Tissues. Gastroenterology 128, No,145, S2, 2005.
Tang Y., Katuri V., Xuefeng L., Schlegel R., Mishra L. Growth regulation by TGF-? is abrogated by multiple mechanisms that include c-myc and h-TERT in gastrointestinal tumors in elf+/-/Smad4+/- mutant mice. Gastroenterology 128, No 4, A-120, 771, S2, 2005.
Tang Y., Katuri V., Xuefeng L., Schlegel R., Mishra L. Growth regulation by TGF-? is abrogated by multiple mechanisms that include c-myc and h-TERT in gastrointestinal tumors in elf+/-/Smad4+/- mutant mice. Gastroenterology 128, No 4, A-120, 771, S2, 2005.
Mishra L. Edip Apkinar, Michael Zasloff, Fishbein Thomas. Dysregulation of TGF-ß Signaling during Small Bowel Allograft Rejection in Humans. Gastroenterology 128, No 4, A-477, T1429, S2, 2005.
Johnson L, Jogunoori W, Tang Y, Katuri V, Shetty K, Mishra B, Mishra L. TGF-ß-signaling is required for normal progenitor cell differentiation and may protect from Insulin induced steatosis in the liver. Hepatology 209, S1, 2005.
Shetty K, Johnson L, Volpe E, Jogunoori W, Tang Y, Katuri V, Mishra L. TGF-ß-signaling pathway inactivation and cell cycle deregulation in human hepatocellular cancer (HCC) cell lines and elf+/-/Smad4+/- tissues. Hepatology 1140, S1, 2005.
Saha T, Yerraguntla D, Tang Y, Katuri V, Jogunoori W, Volpe EA, Haines D, Zhou X, Gallicano I, Schlegel R, Mishra B, Mishra L. 2005. RING Finger-Dependent Ubiquitination by PRAJA is Dependent on TGF-ß and Potentially defines the Functional Status of the Tumor Suppressor ELF. Hepatology 150, S1, 2005.
Kim SS, Baek H, Kang A, Tang Y, Katuri V, Marshall B, Mishra B, Reddy PM, Mishra L. Critical interactions between ELF and CDK4 in regulation of gastrointestinal cell proliferation in TGF- ß signaling pathway. Gastroenterology, Vol 130, No:4, Suppl 2, 83, A-16, 2006.
Golestaneh N, Volpe E,Kanungo J, Evans S, Mishra B, Pant H and Mishra L. ELF phosphorylation by TßRI and Cyclin Dependent Kinases in COs-7 and HepG2 Tumor Cell lines. Gastroenterology, Vol 130, No:4, Suppl 2, 663, A-96, 2006.
Golestaneh N, Tang Y, Katuri V, Mishra B and Mishra L. Signaling pathways in TGF-ß induced tumorigenesis in Elf+/- /Smad4+/- mutant mice cell lines and human gastric tumors. Gastroenterology, Vol 130, No:4, Suppl 2, 864, A-130, 2006.
Katuri V,Tang Y, Jogunoori W, Sidawy A, Mishra B and Mishra L. Cross talk between TGF-ß-IL-6 pathways is important for suppression of hepatocellular cancer. Gastroenterology, Vol 130, No:4, Suppl 2, 866, A-131, 2006.
Saha T, Katuri V, Beak HJ, Kim ss, Tang Y, Jogunoori W, Volpe E, Mishra B and Mishra L. TGF-ß modulates ubiquitination of Tumor suppressor, ELF, and Smad3, by PRAJA, an E3 ligase, that Control Hepatocellular Cancer. Gastroenterology, Vol 130, No:4, Suppl 2, A-530, T1624,2006.
Volpe E, Saha T, Ferguson WJ, Tang Y, Katuri V, Jogunoori W, Mishra B, Mishra L and Evans s. Novel Therapeutic Targets for Gastrointestinal Cancer. Gastroenterology, Vol 130, No:4, Suppl 2, A-538, T1667,2006.
Kitisin K, Ganesan N, Tang Y, Katuri V, Jogunoori W, Mishra B, Shetty K, Johnson L, Mishra L. TGF-ß signaling is required for ductal progenitor cell differentiation and the disruption of TGF-beta signaling may be involved in development of hepatocellular carcinoma and cholangiocarcinoma. Gastroenterology, Vol 130, No:4, Suppl 2, A-539, T1674,2006.
Tang Y, Katuri V, Wang R, Jogunoori W, Saha T, Deng CX, Brandhagen DJ, Sidawy A, Mishra B. and Mishra L. Cross-talk between ELF and HFE is important in suppression of hepatocellular carcinoma. Gastroenterology, Vol 130, No:4, Suppl 2, A-675, W1528, 2006.
Kim SS, Baek H, Katuri V, Saha T, Marshall B, Sidawy AN, Mishra B, Mishra L. Loss of cooperative function of ELF, a ß-spectrin, with Smad3 leads to abnormal localization and transcriptional activation upon TGF-ß response, which is essential for gastrointestinal tumor suppression. Gastroenterology, Vol 130, No:4, Suppl 2, A-680, W1553, 2006.
Kitisin K, Tang Y, Katuri V, Golestaneh N, Jogunoori W, Shetty K, Mishra L, Johnson L. TGF-ß-signaling may play a protective in preventing liver from insulin induced steatosis by regulating insulin driven AKT inactivation of forkhead transcriptional factor proteins. Gastroenterology, Vol 130, No:4, Suppl 2, A-685, W1575, 2006.
Katuri V, Saha T1, Beak H, Kim S, Tang Y, Jogunoori W, Volpe E, Mishra B and Mishra L. PRAJA, a TGF-ß/BMP regulated gene represents a developmental switch between liver and cartilage is regulated in Hepatocellular Cancer. Hepatology Vol 44, No 4, Suppl 1, 257A, 182, 2006.
Kritisin K, Ganesan N, Volpe EA, Kim S, Katuri V, Tang Y, W.Jogunoori, T.Blake, Mishra B, Mishra L, Johnson L, Shetty K. Inactivation and restoration of transforming growth factor-beta signaling modulates hepatocellular carcinogenesis in hepatocellular cancer cell lines and elf +/- tissues. Hepatology Vol 44, No 4, Suppl 1, 595A, 1093, 2006.
Katuri V, Flores E, Tang Y, Jogunoori W, Shetty K, Johnson L, Mishra B and Mishra L. Essential Role of ELF/TGF- ß Signaling in Alcohol-Induced Liver Injury. Hepatology Vol 44, No 4, Suppl 1, 595A, 1094, 2006.
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Tang Y, Katuri V, Jogunoori W, Volpe E, Sidawy A, Mishra B and Mishra L. Cross talk between TGF-? and IL-6 signaling pathways is important for suppression of hepatocellular cancer. Hepatology Vol 44, No 4, Suppl 1, 598A, 1103, 2006.
Tang Yi, Katuri V, Wang R, Jogunoori W, Saha T, Deng C, Brandhagen D, Sidawy A, Mishra B, Mishra L and Tang Y. Crosstalk between ELF and HFE is important in suppression of hepatocellular carcinoma. Hepatology Vol 44, No 4, Suppl 1, 591A, 2006.
Ganesan N, Kitisin K., Tang Y., Katuri V., Shetty K., Johnson L., Mishra L. Identification of human liver progenitor cell populations regulated by TGF-ß signaling that develop an altered phenotype in human hepatocellular cancers. Hepatology Vol 44, No 4, Suppl 1, 474A, 766, 2006.
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